Released on = September 18, 2006, 3:38 pm

Press Release Author = Debra Thai

Industry = Biotech

Press Release Summary = Myelin/oligodendrocyte glycoprotein (MOG) is a 26- to 28-kDa
protein that was first described as a target antigen for the autoimmune
demyelination response observed in animals immunized with CNS homogenates.

Press Release Body = It is a member of the immunoglobulin superfamily expressed in
the central nervous system (CNS) and located within the MHC. Found on the surface of
myelinating oligodendrocytes and external lamellae of myelin sheaths in the CNS, it
is thought to be targeted by the autoimmune T cell response in multiple sclerosis
(MS). Although this protein is a minor component of myelin proteins, MOG is a potent
autoantigen which contributes extensively to the anti-myelin response and primary
inflammatory demyelination in autoimmune diseases. Several lines of evidence suggest
that autoreactive antibodies are important in MS pathogenesis, however the
pathophysiological significance of MOG-specific autoantibodies in MS/EAE is still
controversial. Subtle changes in MOG sequences dramatically influence disease
susceptibility and T cell responses in vitro.

In its continuing effort to provide research solutions for MS, AnaSpec offers MOG
(35 - 55), mouse, rat, a key peptide that induces severe chronic experimental
autoimmune encephalomyelitis in transgenic mice.
· MOG (35-55), mouse, rat

Other fragments of MOG (35-55)*:
· MOG 35-52
· MOG 35-53
· MOG 35-51
· MOG 38-55
· MOG 38-53
· MOG 40-55
· MOG 41-54
· MOG 42-54
· MOG 43-54
· MOG 45-54
· MOG 46-54

* For more information about these additional MOG fragments, contact
service@anaspec.com

For more information, visit www.anaspec.com

References:
1. Delarasse, C. et al. J. Clin. Invest. 112, 544 (2003)
2. Pham-Dinh, D. et al. Proc. Natl. Acad. Sci. USA 3 90, 7990 (1993)
3. Carotenuto, A. et al. J. Med. Chem. 44, 2378 (2001)
4. Bernard, CC. et al. J. Mol. Med. 75, 77 (1997)
5. Iglesias, A. Glia 36, 220 (2001)
6. von Budingen, HC. et al. J. Clin. Immunol. 21, 155 (2001)



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